Rifaximin
Rifaximin is a semi synthetic, rifamycin based non systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics.
Mechanism of action
It act by inhibiting RNA synthesis in susceptible bacteria by binding to the beta- subunit of bacterial DNA dependent RNA polymerase enzyme. this result in blockage of translocation step that normally follows the formation of first phosphodiester bond, which occurs in transcription process.
Side effects
This medication may rarely cause a severe intestinal condition due to a type of resistant bacteria. so you have to consult your doctor if you develop persistent diarrea, abdominal or stomach pain / cramping, blood / mucus in stool .
Uses
This medication is used to treat diarrhea caused by the common bacteria known as E.coli. It shouldn't be used if the patients have fever or bloody diarrhea. This antibiotic treat only bacterial infection. It will not work for viral infection.
Rifaximin is also used to treat irritable bowel syndrome with diarrhea. It is also used to prevent a brain problem caused by liver disease. (hepatic encephalopathy)
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